Family Guy is an animated television series created by Seth MacFarlane. Since premiering January 31, 1999, it has been nominated for twelve Primetime Emmy Awards, winning three.

In a dream "Brian in Love", Mr. Rogers greets the viewers that he is glad together again that he thinks he hears a Trolley ding. Stewie Griffin rides out to the living room on the trolley and tells Rogers that he has taken over the "Neighborhood of Make-Believe" that he says to find it quite and ruined. Rogers immediately investigates and discovers, to his horror, that the "Neighborhood" is a war zone, with several characters screaming over their injuries. Rogers begs for his life, but Stewie uses a laser gun to shoot and kill him, only to find he was dreaming and Mr. Rogers has turned the tables on him, before awakening yet again.

In "Running Mates", Peter Griffin states that he was natural for us to look at naked girls even Mr. Rogers. He spies on his attractive blonde neighbor through his window, greeting her with "Hello Neighbor" as he did at the beginning of every episode of his show.

In "No Chris Left Behind", Stewie declares he can do a better job as monarch of the "Neighborhood of Make Believe". Using puppetry, this gag is furthered when Stewie, as King Friday XIII, rules the land with an iron fist, complaining when the trolley drives by.

In both of his appearances, Mr. Rogers is voiced by Wally Wingert.

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